Evidence of a role for orbital prefrontal cortex in preventing over-generalization to moderate predictors of biologically significant events

Highlights • Role of OPFC in appetitive and aversive context discrimination was assessed in rats. • OPFC was inactivated before assessment of context discrimination. • Rats are unable to constrain conditioned responses during uncertainty. • Rats can show a preference for contexts when all predictive...

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Veröffentlicht in:	Neuroscience 2017-03, Vol.345, p.49-63
Hauptverfasser:	Trow, Jan E, Hong, Nancy S, Jones, Ashley M, Lapointe, Jennifer, MacPhail, Jamie K, McDonald, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catheters, Indwelling Conditioning (Psychology) - physiology context discrimination Discrimination (Psychology) - physiology Discrimination Learning - physiology Electroshock Fear - physiology GABA-A Receptor Agonists - pharmacology generalization Generalization (Psychology) - physiology Male Muscimol - pharmacology Neurology Neuropsychological Tests orbital prefrontal cortex prediction Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Rats, Long-Evans uncertainty
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