Evidence of a role for orbital prefrontal cortex in preventing over-generalization to moderate predictors of biologically significant events

Highlights • Role of OPFC in appetitive and aversive context discrimination was assessed in rats. • OPFC was inactivated before assessment of context discrimination. • Rats are unable to constrain conditioned responses during uncertainty. • Rats can show a preference for contexts when all predictive cues are available. • Data suggests OPFC is important for constraining responses during uncertainty.