Evidence of a role for orbital prefrontal cortex in preventing over-generalization to moderate predictors of biologically significant events
Highlights • Role of OPFC in appetitive and aversive context discrimination was assessed in rats. • OPFC was inactivated before assessment of context discrimination. • Rats are unable to constrain conditioned responses during uncertainty. • Rats can show a preference for contexts when all predictive...
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| Veröffentlicht in: | Neuroscience 2017-03, Vol.345, p.49-63 |
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| container_title | Neuroscience |
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| creator | Trow, Jan E Hong, Nancy S Jones, Ashley M Lapointe, Jennifer MacPhail, Jamie K McDonald, Robert J |
| description | Highlights • Role of OPFC in appetitive and aversive context discrimination was assessed in rats. • OPFC was inactivated before assessment of context discrimination. • Rats are unable to constrain conditioned responses during uncertainty. • Rats can show a preference for contexts when all predictive cues are available. • Data suggests OPFC is important for constraining responses during uncertainty. |
| doi_str_mv | 10.1016/j.neuroscience.2016.10.017 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Neuroscience, 2017-03, Vol.345, p.49-63 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Catheters, Indwelling Conditioning (Psychology) - physiology context discrimination Discrimination (Psychology) - physiology Discrimination Learning - physiology Electroshock Fear - physiology GABA-A Receptor Agonists - pharmacology generalization Generalization (Psychology) - physiology Male Muscimol - pharmacology Neurology Neuropsychological Tests orbital prefrontal cortex prediction Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Rats, Long-Evans uncertainty |
| title | Evidence of a role for orbital prefrontal cortex in preventing over-generalization to moderate predictors of biologically significant events |
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