Occurrence of the Plasmid-Mediated Fluoroquinolone Resistance qepA1 Gene in Two Clonal Clinical Isolates of CTX-M-15-Producing Escherichia coli from Algeria

QepA is a plasmid-mediated quinolone resistance determinant of low prevalence described worldwide, mainly in Enterobacteriaceae . This study describes, for the first time in Algeria, two clonally related, QepA-producing Escherichia coli clinical isolates positive for CTX-M-15. The clonal spread of t...

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Veröffentlicht in:	Microbial drug resistance (Larchmont, N.Y.) N.Y.), 2017-06, Vol.23 (4), p.497-499
Hauptverfasser:	Yanat, Betitera, Dali Yahia, Radia, Yazi, Leila, Machuca, Jesús, Díaz-De-Alba, Paula, Touati, Abdelaziz, Pascual, Álvaro, Rodríguez-Martínez, José-Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Algeria Anti-Bacterial Agents - pharmacology Antibiotics beta-Lactamases - genetics beta-Lactamases - metabolism Clinical isolates Clone Cells Drug resistance Drug Resistance, Multiple, Bacterial - genetics E coli Electrophoresis, Gel, Pulsed-Field Epidemiology Escherichia coli - classification Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - isolation & purification Escherichia coli Infections - drug therapy Escherichia coli Infections - microbiology Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Fluoroquinolones - pharmacology Gene Expression Genes Humans Multidrug resistance Phylogeny Plasmids - chemistry Plasmids - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism Public health
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Zusammenfassung:	QepA is a plasmid-mediated quinolone resistance determinant of low prevalence described worldwide, mainly in Enterobacteriaceae . This study describes, for the first time in Algeria, two clonally related, QepA-producing Escherichia coli clinical isolates positive for CTX-M-15. The clonal spread of these multidrug-resistant isolates is a major public health concern.
ISSN:	1076-6294 1931-8448
DOI:	10.1089/mdr.2016.0135