Antimalarial activity of the terpene nerolidol

Highlights • Nerolidol had an antimalarial effect in a murine malaria model. • Nerolidol was non-toxic and non-genotoxic up to doses of 6.5 µM. • AUC0–12 values were 0.46 µM⋅h and 11.19 µM⋅h by inhalation and oral routes, respectively. • Parasitaemia was almost abolished by Day 15 of oral nerolidol...

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Veröffentlicht in:	International journal of antimicrobial agents 2016-12, Vol.48 (6), p.641-646
Hauptverfasser:	Saito, Alexandre Y, Marin Rodriguez, Adriana A, Menchaca Vega, Danielle S, Sussmann, Rodrigo A.C, Kimura, Emília A, Katzin, Alejandro M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Administration, Oral Animals Antimalarials - administration & dosage Antimalarials - adverse effects Antimalarials - pharmacology BALB/c mice Disease Models, Animal Drug-Related Side Effects and Adverse Reactions Infectious Disease Isoprenoids Malaria Malaria - drug therapy Male Mice, Inbred BALB C Nerolidol Parasitemia - drug therapy Plasmodium berghei - drug effects Plasmodium berghei ANKA Sesquiterpenes - administration & dosage Sesquiterpenes - adverse effects Sesquiterpenes - pharmacology Survival Analysis Terpenes Terpenes - pharmacology Treatment Outcome
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Zusammenfassung:	Highlights • Nerolidol had an antimalarial effect in a murine malaria model. • Nerolidol was non-toxic and non-genotoxic up to doses of 6.5 µM. • AUC0–12 values were 0.46 µM⋅h and 11.19 µM⋅h by inhalation and oral routes, respectively. • Parasitaemia was almost abolished by Day 15 of oral nerolidol treatment.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2016.08.017