Delivery methods to increase cellular uptake and immunogenicity of DNA vaccines

Delivery methods to increase cellular uptake and immunogenicity of DNA vaccines

Abstract DNA vaccines are ideal candidates for global vaccination purposes because they are inexpensive and easy to manufacture on a large scale such that even people living in low-income countries can benefit from vaccination. However, the potential of DNA vaccines has not been realized owing mainl...

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Veröffentlicht in:Vaccine 2016-11, Vol.34 (46), p.5488-5494
Hauptverfasser: Jorritsma, S.H.T, Gowans, E.J, Grubor-Bauk, B, Wijesundara, D.K
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Antigen-Presenting Cells - immunology
Antigens
Biolistics
Deoxyribonucleic acid
DNA
DNA delivery
DNA immunogenicity
DNA vaccination
Electroporation
Hepatitis
HIV
Human immunodeficiency virus
Humans
Immunogenicity
Immunogenicity, Vaccine
Injections, Intramuscular
Liposomes
Low income areas
Methods
Mice
Nanoparticles
Rodents
Smallpox
Studies
Subcutaneous Absorption
Vaccination - methods
Vaccines
Vaccines, DNA
Viruses
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Zusammenfassung:Abstract DNA vaccines are ideal candidates for global vaccination purposes because they are inexpensive and easy to manufacture on a large scale such that even people living in low-income countries can benefit from vaccination. However, the potential of DNA vaccines has not been realized owing mainly to the poor cellular uptake of DNA in vivo resulting in the poor immunogenicity of DNA vaccines. In this review, we discuss the benefits and shortcomings of several promising and innovative non-biological methods of DNA delivery that can be used to increase cellular delivery and efficacy of DNA vaccines.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.09.062