Comparison of serum thiol–disulphide homeostasis and total antioxidant–oxidant levels between exudative age-related macular degeneration patients and healthy subjects

Purpose The purpose of the study was to calculate serum total oxidant status (TOS), total antioxidant status (TAS), and dynamic thiol–disulphide (T-D) homeostasis in patients with age-related macular degeneration (AMD), and compare the results with healthy individuals. Methods Thirty-three exudative AMD patients and 33 healthy controls were included in this case–control study. Participants’ serum TAS and TOS levels were measured. In addition, total thiol (TT), native thiol (NT), and disulphide (DS) concentrations were assessed using a novel automated method of measurement. Results In comparison with the control group, serum TAS, TT, and NT levels were found to be significantly lower ( p