Does topical ozone therapy improve patient comfort after surgical removal of impacted mandibular third molar? - A randomized controlled trial
Abstract Objectives To assess the influence of topical ozone administration on patient comfort following third molar surgery. Materials and Methods A single blind randomized controlled clinical trial was designed involving patients who required removal of bilateral impacted mandibular third molars....
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| Veröffentlicht in: | Journal of oral and maxillofacial surgery 2017-01, Vol.75 (1), p.51.e1-51.e9 |
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| container_title | Journal of oral and maxillofacial surgery |
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| creator | Varun Prasad, S., BDS Elavenil, P., MDS, MBA Krishnakumar Raja, V.B., MDS Gayathri, Gopi, MDS |
| description | Abstract Objectives To assess the influence of topical ozone administration on patient comfort following third molar surgery. Materials and Methods A single blind randomized controlled clinical trial was designed involving patients who required removal of bilateral impacted mandibular third molars. The predictor variable was the post-operative medication used after third molar surgery. Using the split mouth design, the study group received topical ozone without post-operative systemic antibiotics while the control group did not receive ozone but only systemic antibiotics. Both the groups were prescribed analgesics for 2 days. The assessing surgeon was blinded to treatment assignment. The primary outcome variables were post- operative mouth opening, pain and swelling. The secondary outcome variable was the number of analgesic doses required by each group on the 3rd , 4th & 5th post-operative days. Data analysis involved, descriptive statistics, paired t tests and two-way ANOVA with repeated measures (p |
| doi_str_mv | 10.1016/j.joms.2016.09.014 |
| format | Article |
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Materials and Methods A single blind randomized controlled clinical trial was designed involving patients who required removal of bilateral impacted mandibular third molars. The predictor variable was the post-operative medication used after third molar surgery. Using the split mouth design, the study group received topical ozone without post-operative systemic antibiotics while the control group did not receive ozone but only systemic antibiotics. Both the groups were prescribed analgesics for 2 days. The assessing surgeon was blinded to treatment assignment. The primary outcome variables were post- operative mouth opening, pain and swelling. The secondary outcome variable was the number of analgesic doses required by each group on the 3rd , 4th & 5th post-operative days. Data analysis involved, descriptive statistics, paired t tests and two-way ANOVA with repeated measures (p<0.05). SPSS version 20.0 was used for data analysis. Results The study sample included 33 subjects (n=33 in each group). The study group demonstrated statistically significant reduction in post-operative pain, swelling and trismus. Further, the number of analgesics required was less than the control group. No adverse effects of ozone gel was observed in any patient. Conclusion Ozone gel was found to be an effective topical agent that considerably improves patient comfort post-operatively and may be considered a substitute to post-operative systemic antibiotics.</description><identifier>ISSN: 0278-2391</identifier><identifier>EISSN: 1531-5053</identifier><identifier>DOI: 10.1016/j.joms.2016.09.014</identifier><identifier>PMID: 27741414</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Administration, Topical ; Adult ; Anesthesia, Dental - methods ; Dentistry ; Female ; Gels ; Humans ; Male ; Molar, Third - surgery ; Ozone - administration & dosage ; Ozone - therapeutic use ; Pain, Postoperative - prevention & control ; Single-Blind Method ; Surgery ; Tooth Extraction - methods ; Tooth, Impacted - surgery ; Treatment Outcome</subject><ispartof>Journal of oral and maxillofacial surgery, 2017-01, Vol.75 (1), p.51.e1-51.e9</ispartof><rights>2016 American Association of Oral and Maxillofacial Surgeons</rights><rights>Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-4c48fd6993fdbf139a6dec4d4837915adefb6d7e3f44d884c3821c76c64534cb3</citedby><cites>FETCH-LOGICAL-c411t-4c48fd6993fdbf139a6dec4d4837915adefb6d7e3f44d884c3821c76c64534cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278239116308217$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27741414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Varun Prasad, S., BDS</creatorcontrib><creatorcontrib>Elavenil, P., MDS, MBA</creatorcontrib><creatorcontrib>Krishnakumar Raja, V.B., MDS</creatorcontrib><creatorcontrib>Gayathri, Gopi, MDS</creatorcontrib><title>Does topical ozone therapy improve patient comfort after surgical removal of impacted mandibular third molar? - A randomized controlled trial</title><title>Journal of oral and maxillofacial surgery</title><addtitle>J Oral Maxillofac Surg</addtitle><description>Abstract Objectives To assess the influence of topical ozone administration on patient comfort following third molar surgery. Materials and Methods A single blind randomized controlled clinical trial was designed involving patients who required removal of bilateral impacted mandibular third molars. The predictor variable was the post-operative medication used after third molar surgery. Using the split mouth design, the study group received topical ozone without post-operative systemic antibiotics while the control group did not receive ozone but only systemic antibiotics. Both the groups were prescribed analgesics for 2 days. The assessing surgeon was blinded to treatment assignment. The primary outcome variables were post- operative mouth opening, pain and swelling. The secondary outcome variable was the number of analgesic doses required by each group on the 3rd , 4th & 5th post-operative days. Data analysis involved, descriptive statistics, paired t tests and two-way ANOVA with repeated measures (p<0.05). SPSS version 20.0 was used for data analysis. Results The study sample included 33 subjects (n=33 in each group). The study group demonstrated statistically significant reduction in post-operative pain, swelling and trismus. Further, the number of analgesics required was less than the control group. No adverse effects of ozone gel was observed in any patient. Conclusion Ozone gel was found to be an effective topical agent that considerably improves patient comfort post-operatively and may be considered a substitute to post-operative systemic antibiotics.</description><subject>Administration, Topical</subject><subject>Adult</subject><subject>Anesthesia, Dental - methods</subject><subject>Dentistry</subject><subject>Female</subject><subject>Gels</subject><subject>Humans</subject><subject>Male</subject><subject>Molar, Third - surgery</subject><subject>Ozone - administration & dosage</subject><subject>Ozone - therapeutic use</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Single-Blind Method</subject><subject>Surgery</subject><subject>Tooth Extraction - methods</subject><subject>Tooth, Impacted - surgery</subject><subject>Treatment Outcome</subject><issn>0278-2391</issn><issn>1531-5053</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk1v1DAUtBCIbgt_gAPykUuCX-x8SQhUtRSQKnEAzpZjP4OXJA62s9L2P_CfcdjCgQPywSN7ZqQ38wh5BqwEBs3Lfbn3UyyrjEvWlwzEA7KDmkNRs5o_JDtWtV1R8R7OyHmMe8YA6rZ5TM6qthWQz478vPYYafKL02qk_s7PSNM3DGo5UjctwR-QLio5nBPVfrI-JKpswkDjGr7-FgWc_GET202hdEJDJzUbN6yjCtnNhfzgM35DC3pJQ_7zk7vLNO3nFPw4ZpiCU-MT8siqMeLT-_uCfLl5-_nqfXH78d2Hq8vbQguAVAgtOmuavufWDBZ4rxqDWhjR8baHWhm0Q2Na5FYI03VC864C3Ta6ETUXeuAX5MXJNw_4Y8WY5OSixnFUM_o1Suh4LYC1nGVqdaLq4GMMaOUS3KTCUQKTWw1yL7ca5FaDZL3MNWTR83v_dZjQ_JX8yT0TXp0ImKc8OAwy6pyxRuMC6iSNd__3f_2PXI9u3tr4jkeMe7-GOecnQcZKMvlpW4RtD6DhLEfR8l8k-rEq</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Varun Prasad, S., BDS</creator><creator>Elavenil, P., MDS, MBA</creator><creator>Krishnakumar Raja, V.B., MDS</creator><creator>Gayathri, Gopi, MDS</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>Does topical ozone therapy improve patient comfort after surgical removal of impacted mandibular third molar? - A randomized controlled trial</title><author>Varun Prasad, S., BDS ; Elavenil, P., MDS, MBA ; Krishnakumar Raja, V.B., MDS ; Gayathri, Gopi, MDS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-4c48fd6993fdbf139a6dec4d4837915adefb6d7e3f44d884c3821c76c64534cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Administration, Topical</topic><topic>Adult</topic><topic>Anesthesia, Dental - methods</topic><topic>Dentistry</topic><topic>Female</topic><topic>Gels</topic><topic>Humans</topic><topic>Male</topic><topic>Molar, Third - surgery</topic><topic>Ozone - administration & dosage</topic><topic>Ozone - therapeutic use</topic><topic>Pain, Postoperative - prevention & control</topic><topic>Single-Blind Method</topic><topic>Surgery</topic><topic>Tooth Extraction - methods</topic><topic>Tooth, Impacted - surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Varun Prasad, S., BDS</creatorcontrib><creatorcontrib>Elavenil, P., MDS, MBA</creatorcontrib><creatorcontrib>Krishnakumar Raja, V.B., MDS</creatorcontrib><creatorcontrib>Gayathri, Gopi, MDS</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Varun Prasad, S., BDS</au><au>Elavenil, P., MDS, MBA</au><au>Krishnakumar Raja, V.B., MDS</au><au>Gayathri, Gopi, MDS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does topical ozone therapy improve patient comfort after surgical removal of impacted mandibular third molar? - A randomized controlled trial</atitle><jtitle>Journal of oral and maxillofacial surgery</jtitle><addtitle>J Oral Maxillofac Surg</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>75</volume><issue>1</issue><spage>51.e1</spage><epage>51.e9</epage><pages>51.e1-51.e9</pages><issn>0278-2391</issn><eissn>1531-5053</eissn><abstract>Abstract Objectives To assess the influence of topical ozone administration on patient comfort following third molar surgery. Materials and Methods A single blind randomized controlled clinical trial was designed involving patients who required removal of bilateral impacted mandibular third molars. The predictor variable was the post-operative medication used after third molar surgery. Using the split mouth design, the study group received topical ozone without post-operative systemic antibiotics while the control group did not receive ozone but only systemic antibiotics. Both the groups were prescribed analgesics for 2 days. The assessing surgeon was blinded to treatment assignment. The primary outcome variables were post- operative mouth opening, pain and swelling. The secondary outcome variable was the number of analgesic doses required by each group on the 3rd , 4th & 5th post-operative days. Data analysis involved, descriptive statistics, paired t tests and two-way ANOVA with repeated measures (p<0.05). SPSS version 20.0 was used for data analysis. Results The study sample included 33 subjects (n=33 in each group). The study group demonstrated statistically significant reduction in post-operative pain, swelling and trismus. Further, the number of analgesics required was less than the control group. No adverse effects of ozone gel was observed in any patient. Conclusion Ozone gel was found to be an effective topical agent that considerably improves patient comfort post-operatively and may be considered a substitute to post-operative systemic antibiotics.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27741414</pmid><doi>10.1016/j.joms.2016.09.014</doi></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Topical Adult Anesthesia, Dental - methods Dentistry Female Gels Humans Male Molar, Third - surgery Ozone - administration & dosage Ozone - therapeutic use Pain, Postoperative - prevention & control Single-Blind Method Surgery Tooth Extraction - methods Tooth, Impacted - surgery Treatment Outcome |
| title | Does topical ozone therapy improve patient comfort after surgical removal of impacted mandibular third molar? - A randomized controlled trial |
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