Does topical ozone therapy improve patient comfort after surgical removal of impacted mandibular third molar? - A randomized controlled trial

Abstract Objectives To assess the influence of topical ozone administration on patient comfort following third molar surgery. Materials and Methods A single blind randomized controlled clinical trial was designed involving patients who required removal of bilateral impacted mandibular third molars. The predictor variable was the post-operative medication used after third molar surgery. Using the split mouth design, the study group received topical ozone without post-operative systemic antibiotics while the control group did not receive ozone but only systemic antibiotics. Both the groups were prescribed analgesics for 2 days. The assessing surgeon was blinded to treatment assignment. The primary outcome variables were post- operative mouth opening, pain and swelling. The secondary outcome variable was the number of analgesic doses required by each group on the 3rd , 4th & 5th post-operative days. Data analysis involved, descriptive statistics, paired t tests and two-way ANOVA with repeated measures (p