The synergistic effect of photodynamic therapy and photothermal therapy in the presence of gold-gold sulfide nanoshells conjugated Indocyanine green on HeLa cells

Highlights • We bonded Indocyanine Green to gold nanoshells GGS by the interaction between metallic nanomaterials and the excited state fluorophores of ICG to produce dipoles behavior. • Due to the lack of an effective and complete response for cervix cancer to conventional therapies, this study was...

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Veröffentlicht in:	Photodiagnosis and photodynamic therapy 2017-03, Vol.17, p.48-55
Hauptverfasser:	Ghorbani, Farzaneh, MSc in Medical Physics, Attaran-Kakhki, Neda, Sazgarnia, Ameneh
Format:	Artikel
Sprache:	eng
Schlagworte:	Au-Au2S (GGS) Cell Death Gold - chemistry HeLa Cells Hematology, Oncology and Palliative Medicine Humans Indocyanine green (ICG) Indocyanine Green - chemistry Indocyanine Green - pharmacology Internal Medicine Microscopy, Electron, Scanning Nanoshells - chemistry Particle Size Photochemotherapy - methods Photodynamic therapy (PDT) Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Photothermal therapy (PTT) Technology, Pharmaceutical
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Zusammenfassung:	Highlights • We bonded Indocyanine Green to gold nanoshells GGS by the interaction between metallic nanomaterials and the excited state fluorophores of ICG to produce dipoles behavior. • Due to the lack of an effective and complete response for cervix cancer to conventional therapies, this study was performed on the HeLa cell line derived from cervix cancer. • The conjugate provided a synergism between PDT and PTT. So, it is suggested the conjugate be considered as an effective agent for PTT and/or PDT.
ISSN:	1572-1000 1873-1597
DOI:	10.1016/j.pdpdt.2016.10.002