MSCs can be differentially isolated from maternal, middle and fetal segments of the human umbilical cord

Highlights • We compared MSCs isolated from 3 anatomical segments of umbilical cord (maternal, middle and foetal). • Results showed that the cells exhibited different growth rate, expression of embryonic markers and multilineage differentiation potential. • The selection of umbilical cord segments f...

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Veröffentlicht in:	Cytotherapy (Oxford, England) England), 2016-12, Vol.18 (12), p.1493-1502
Hauptverfasser:	Lim, Jezamine, Razi, Zainul Rashid Mohamad, Law, Jiaxian, Nawi, Azmawati Mohammed, Idrus, Ruszymah Binti Haji, Ng, Min Hwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis - physiology Adult Advanced Basic Science Biomarkers - metabolism Cell Differentiation Cell Proliferation Cell Survival Cells, Cultured Chondrogenesis - physiology Flow Cytometry Humans Immunophenotyping Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Osteogenesis - physiology Other regenerative medicine stromal cells Stromal Cells - cytology tissue engineering umbilical cord Umbilical Cord - cytology Wharton Jelly - cytology Wharton's jelly
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Zusammenfassung:	Highlights • We compared MSCs isolated from 3 anatomical segments of umbilical cord (maternal, middle and foetal). • Results showed that the cells exhibited different growth rate, expression of embryonic markers and multilineage differentiation potential. • The selection of umbilical cord segments for cell isolation is important to harvest MSCs with best therapeutic potential.
ISSN:	1465-3249 1477-2566
DOI:	10.1016/j.jcyt.2016.08.003