Brain Metastasis Prediction by Transcriptomic Profiling in Triple-Negative Breast Cancer

Micro-Abstract We investigated expression of 29,369 gene transcripts in primary tumor samples from 119 patients with advanced triple-negative breast cancer to identify genes with different expression between patients with and without brain metastases (BM). Our results indicate that analysis based on...

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Veröffentlicht in:	Clinical breast cancer 2017-04, Vol.17 (2), p.e65-e75
Hauptverfasser:	Duchnowska, Renata, Jarząb, Michał, Żebracka-Gala, Jadwiga, Matkowski, Rafał, Kowalczyk, Anna, Radecka, Barbara, Kowalska, Małgorzata, Pfeifer, Aleksandra, Foszczyńska-Kłoda, Małgorzata, Musolino, Antonino, Czartoryska-Arłukowicz, Bogumiła, Litwiniuk, Maria, Surus-Hyla, Anna, Szabłowska-Siwik, Sylwia, Karczmarek-Borowska, Bożenna, Dębska-Szmich, Sylwia, Głodek-Sutek, Beata, Sosińska-Mielcarek, Katarzyna, Chmielowska, Ewa, Kalinka-Warzocha, Ewa, Olszewski, Wojciech P, Patera, Janusz, Żawrocki, Anton, Pliszka, Agnieszka, Tyszkiewicz, Tomasz, Rusinek, Dagmara, Oczko-Wojciechowska, Małgorzata, Jassem, Jacek, Biernat, Wojciech
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Brain metastasis Brain Neoplasms - diagnosis Brain Neoplasms - epidemiology Brain Neoplasms - secondary cDNA-mediated annealing, extension, and ligation (DASL) assay Estrogen Receptor alpha - metabolism Female Follow-Up Studies Gene Expression Profiling Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Middle Aged Neoplasm Staging Obstetrics and Gynecology Prognosis Receptor, ErbB-2 - metabolism Receptors, Progesterone - metabolism Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Selection Transcriptomic profiling Triple negative breast cancer Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology
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Zusammenfassung:	Micro-Abstract We investigated expression of 29,369 gene transcripts in primary tumor samples from 119 patients with advanced triple-negative breast cancer to identify genes with different expression between patients with and without brain metastases (BM). Our results indicate that analysis based on expression of gene transcripts from primary tumor does not allow prediction of BM development in this population.
ISSN:	1526-8209 1938-0666
DOI:	10.1016/j.clbc.2016.08.008