Effects of Differentiation and Antisenescence from BMSCs to Hepatocy-Like Cells of the PAAm-IGF-1/TNF‑α Biomaterial

Effects of Differentiation and Antisenescence from BMSCs to Hepatocy-Like Cells of the PAAm-IGF-1/TNF‑α Biomaterial

Aiming at the cells’ differentiation phenomenon and senescence problem in liver tissue engineering, this work is designed to synthesize three different chargeable polymers (polypropylene acid (PAAc), polyethylene glycol (PEG), and polypropylene amine (PAAm)) coimmobilized by the insulin-like growth...

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Veröffentlicht in:ACS applied materials & interfaces 2016-10, Vol.8 (40), p.26638-26647
Hauptverfasser: Yang, Runcai, Wu, Lifang, Chen, Jiehong, Chen, Wuya, Zhang, Lin, Zhang, Li, You, Rong, Yin, Liang, Li, Chu-Hua, Guan, Yan-Qing
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container_end_page 26647
container_issue 40
container_start_page 26638
container_title ACS applied materials & interfaces
container_volume 8
creator Yang, Runcai
Wu, Lifang
Chen, Jiehong
Chen, Wuya
Zhang, Lin
Zhang, Li
You, Rong
Yin, Liang
Li, Chu-Hua
Guan, Yan-Qing
description Aiming at the cells’ differentiation phenomenon and senescence problem in liver tissue engineering, this work is designed to synthesize three different chargeable polymers (polypropylene acid (PAAc), polyethylene glycol (PEG), and polypropylene amine (PAAm)) coimmobilized by the insulin-like growth factor 1 (IGF-1) and tumor necrosis factor-α (TNF-α). We explore the hepatocyte differentiation effect and the antisenecence effect of PSt-PAAm-IGF-1/TNF-α biomaterial which was selected from the three different chargeable polymers in bone marrow mesenchymal stem cells (BMSCs). Our work will establish a model for studying the biochemical molecular regulation mechanism and signal transduction pathway of cell senescence in liver tissue engineering, which provide a molecular basis for developing biomaterials for liver tissue engineering.
doi_str_mv 10.1021/acsami.6b10377
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title Effects of Differentiation and Antisenescence from BMSCs to Hepatocy-Like Cells of the PAAm-IGF-1/TNF‑α Biomaterial
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