Synthesis of Nitrogen Heterocycles via Photochemical Ring Opening of Pyridazine N‑Oxides

Synthesis of Nitrogen Heterocycles via Photochemical Ring Opening of Pyridazine N‑Oxides

A photochemical method for the direct synthesis of 1H-pyrazoles from pyridazine N-oxides was developed. This chemistry features a regioselective approach to nonsymmetrically substituted pyridazine N-oxides. Herein, we highlight the first strategic use of photoinduced ring-opening reactions of 1,2-di...

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Veröffentlicht in:Organic letters 2016-10, Vol.18 (19), p.5142-5145
Hauptverfasser: Portillo, Maribel, Maxwell, Michael A, Frederich, James H
Format: Artikel
Sprache:eng
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Zusammenfassung:A photochemical method for the direct synthesis of 1H-pyrazoles from pyridazine N-oxides was developed. This chemistry features a regioselective approach to nonsymmetrically substituted pyridazine N-oxides. Herein, we highlight the first strategic use of photoinduced ring-opening reactions of 1,2-diazine N-oxides for the preparative synthesis of nitrogen heterocycles.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b02562