Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors

[Display omitted] Herein, we describe our research efforts to develop unique cores in molecules which function as HCV nonstructural protein 5A (NS5A) inhibitors. In particular, various fused tetracyclic cores were identified which showed genotype and mutant activities comparable to the indole-based...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-10, Vol.26 (20), p.5132-5137
Hauptverfasser:	Tong, Ling, Yu, Wensheng, Coburn, Craig A., Meinke, Peter T., Nair, Anilkumar G., Dwyer, Michael P., Chen, Lei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Fells, James, Hu, Bin, Zhong, Bin, Soll, Richard M., Liu, Rong, Agrawal, Sony, Xia, Ellen, Zhai, Ying, Kong, Rong, Ingravallo, Paul, Nomeir, Amin, Asante-Appiah, Ernest, Kozlowski, Joseph A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology DAA Direct-acting antiviral agents Elbasvir HCV infection treatment HCV NS5A inhibitor Hepacivirus - drug effects Indoles - pharmacology MK-8742 Tetracyclic core Viral Nonstructural Proteins - antagonists & inhibitors
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Zusammenfassung:	[Display omitted] Herein, we describe our research efforts to develop unique cores in molecules which function as HCV nonstructural protein 5A (NS5A) inhibitors. In particular, various fused tetracyclic cores were identified which showed genotype and mutant activities comparable to the indole-based tetracyclic core.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2016.07.057