Long-Term Results of Pro Re Nata Regimen of Aflibercept Treatment in Persistent Neovascular Age-Related Macular Degeneration

Repeated injections of aflibercept showed no significant visual acuity gain, probably owing to the chronicity of neovascular membrane and macular atrophy.4 Baseline optical coherence tomography indicators like increased central subfield thickness, presence of intraretinal cysts, presence of pigment epithelial detachment, and subfoveal thickening indicate poor prognosis to treatment with intravitreal aflibercept.5 To conclude, the decision to switch from ranibizumab and/or bevacizumab injections to intravitreal aflibercept injections in patients with multiple recurrences or persistent fluid must also be based on the baseline OCT features, baseline visual acuity, and chances of visual acuity gain.