Cholinergic agonist reverses H1-induced memory deficit in mice

Cholinergic agonist reverses H1-induced memory deficit in mice

This study investigated the effects of bilateral intraamygdalar microinjections of PNU-282987, a nicotinic cholinergic agonist, on anxiety and the reversal of amnesia induced by chlorpheniramine (CPA), an H1 histaminergic antagonist, in mice subjected to the elevated plusmaze (EPM). Two experiments...

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Veröffentlicht in:Progress in neuro-psychopharmacology & biological psychiatry 2017-01, Vol.72, p.16-22
Hauptverfasser: Fernandes, C.E.M., Serafim, K.R., Gianlorenço, A.C.L., Mattioli, R.
Format: Artikel
Sprache:eng
Schlagworte:
Amygdala
Amygdala - drug effects
Amygdala - physiology
Analysis of Variance
Animals
Benzamides - therapeutic use
Bridged Bicyclo Compounds - therapeutic use
Chlorpheniramine
Chlorpheniramine - toxicity
Disease Models, Animal
Dose-Response Relationship, Drug
Elevated plus-maze
Emotional memory
Histamine H1 Antagonists - toxicity
Male
Maze Learning - drug effects
Memory Disorders - chemically induced
Memory Disorders - drug therapy
Mice
Microinjections
Nicotinic Agonists - therapeutic use
PNU-282987
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Zusammenfassung:This study investigated the effects of bilateral intraamygdalar microinjections of PNU-282987, a nicotinic cholinergic agonist, on anxiety and the reversal of amnesia induced by chlorpheniramine (CPA), an H1 histaminergic antagonist, in mice subjected to the elevated plusmaze (EPM). Two experiments were performed with seventy-nine adult male Swiss mice. The isolated microinjections of PNU-282987 did not produce effects on emotional memory; however, the combined microinjections of PNU-282987 and CPA were able to reverse the deficit in memory induced by CPA (ANOVA, p
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2016.08.007