Dose–response of intrathecal morphine when administered with intravenous ketorolac for post-cesarean analgesia: a two-center, prospective, randomized, blinded trial

Highlights • Intrathecal morphine in post-cesarean patients who received intravenous ketorolac was investigated. • Intrathecal morphine 50 μg produced comparable analgesia to 100 and 150 μg. • Visual analogue scores for pain, nausea and satisfaction were similar between groups. • Pruritus was higher...

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Veröffentlicht in:	International journal of obstetric anesthesia 2016-12, Vol.28, p.3-11
Hauptverfasser:	Berger, J.S, Gonzalez, A, Hopkins, A, Alshaeri, T, Jeon, D, Wang, S, Amdur, R.L, Smiley, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analgesia Analgesia - methods Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacology Anesthesia & Perioperative Care Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Cesarean delivery Cesarean Section Dose-Response Relationship, Drug Female Humans Injections, Spinal Intrathecal Ketorolac Ketorolac - administration & dosage Morphine Morphine - administration & dosage Morphine - pharmacology Obstetrics and Gynecology Pain, Postoperative - drug therapy Prospective Studies Treatment Outcome
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Zusammenfassung:	Highlights • Intrathecal morphine in post-cesarean patients who received intravenous ketorolac was investigated. • Intrathecal morphine 50 μg produced comparable analgesia to 100 and 150 μg. • Visual analogue scores for pain, nausea and satisfaction were similar between groups. • Pruritus was higher with 100 and 150 μg versus 50 μg. • No instances of respiratory depression or significant sedation.
ISSN:	0959-289X 1532-3374
DOI:	10.1016/j.ijoa.2016.08.003