Nickel-Catalyzed ortho-C‑H Thiolation of N‑Benzoyl α‑Amino Acid Derivatives

Nickel-Catalyzed ortho-C‑H Thiolation of N‑Benzoyl α‑Amino Acid Derivatives

We developed the first nickel-catalyzed direct ortho-thiolation of N-benzoyl α-amino acid derivatives. This novel strategy showed wide generality, functional tolerance, and high regioselectivity. In addition, dipeptide derivatives were also compatible with this transformation system, providing a pot...

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Veröffentlicht in:Journal of organic chemistry 2016-10, Vol.81 (19), p.9122-9130
Hauptverfasser: Gao, Feng, Zhu, Wei, Zhang, Dengyou, Li, Shuangjie, Wang, Jiang, Liu, Hong
Format: Artikel
Sprache:eng
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Zusammenfassung:We developed the first nickel-catalyzed direct ortho-thiolation of N-benzoyl α-amino acid derivatives. This novel strategy showed wide generality, functional tolerance, and high regioselectivity. In addition, dipeptide derivatives were also compatible with this transformation system, providing a potential protocol for the direct modification of peptide derivatives.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.6b01702