Nanohybride Materials Based on Magnetite-Gold Nanoparticles for Diagnostics of Prostate Cancer: Synthesis and In Vitro Testing

We synthesized a fluorescence conjugate and modified magnetite-gold nanoparticles carrying prostate specific membrane antigen (PSMA) as the ligand. Analysis of their binding to human prostate cancer cell lines PC-3 (PSMA – ) and LNCaP (PSMA + ) showed selective interaction of the synthesized conjuga...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2016-09, Vol.161 (5), p.706-710
Hauptverfasser:	Machulkin, A. E., Garanina, A. S., Zhironkina, O. A., Beloglazkina, E. K., Zyk, N. V., Savchenko, A. G., Kotelyanskii, V. E., Mazhuga, A. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Biotechnologies Blood tests Care and treatment Cell Biology Cell Line, Tumor Colorectal cancer Contrast Media - chemical synthesis Contrast Media - metabolism Cytoplasm - metabolism Diagnostic imaging Gold - chemistry Humans Internal Medicine Laboratory Medicine Liver cancer Magnetite Magnetite Nanoparticles - chemistry Male Nanoconjugates - chemistry Nanoparticles Pathology Prostate cancer Prostate specific antigen Prostatic Neoplasms - diagnostic imaging Stomach cancer
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Zusammenfassung:	We synthesized a fluorescence conjugate and modified magnetite-gold nanoparticles carrying prostate specific membrane antigen (PSMA) as the ligand. Analysis of their binding to human prostate cancer cell lines PC-3 (PSMA – ) and LNCaP (PSMA + ) showed selective interaction of the synthesized conjugate and modified nanoparticles with LNCaP cells. These findings suggest that these nanoparticles can be used in tissue-specific magnetic-resonance imaging.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-016-3490-3