Promotion of enamel caries remineralization by an amelogenin-derived peptide in a rat model

Highlights • A novel peptide based on amelogenin had been confirmed to promote remineralization in an in vitro pH-cycling model. • A classic animal caries model was adopted to explore whether this peptide has same effects in vivo. • This amelogenin-based peptide can promote remineralization in rat c...

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Veröffentlicht in:	Archives of oral biology 2017-01, Vol.73, p.66-71
Hauptverfasser:	Han, Sili, Fan, Yingying, Zhou, Zhengli, Tu, Huanxin, Li, Danxue, Lv, Xueping, Ding, Longjiang, Zhang, Linglin
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Amelogenin Amelogenin - pharmacology Animals Caries Cariostatic Agents - pharmacology Dental Caries - pathology Dentistry Disease Models, Animal Hydrogen-Ion Concentration In Vitro Techniques In vivo model Microscopy, Polarization Minerals - metabolism Peptide Peptides - pharmacology Random Allocation Rat Rats Rats, Sprague-Dawley Remineralization Sodium Fluoride - pharmacology Streptococcus mutans Tooth Remineralization - methods
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Zusammenfassung:	Highlights • A novel peptide based on amelogenin had been confirmed to promote remineralization in an in vitro pH-cycling model. • A classic animal caries model was adopted to explore whether this peptide has same effects in vivo. • This amelogenin-based peptide can promote remineralization in rat caries model. • This peptide shows strong potential for treating enamel caries in clinic.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2016.09.009