A Regioselective Metal-Free Construction of 3‑Aroyl Coumarins by Csp2‑H Functionalization
A successive metal-free TBHP-mediated regioselective C–H functionalization of coumarins toward expedient synthesis of 3-aroyl coumarins is unveiled. The ongoing method conducted through the reaction of either coumarins or coumarin-3-carboxylic acids with aromatic aldehydes. The optimized reaction co...
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| Veröffentlicht in: | Journal of organic chemistry 2016-12, Vol.81 (23), p.11982-11986 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A successive metal-free TBHP-mediated regioselective C–H functionalization of coumarins toward expedient synthesis of 3-aroyl coumarins is unveiled. The ongoing method conducted through the reaction of either coumarins or coumarin-3-carboxylic acids with aromatic aldehydes. The optimized reaction condition also worked well with benzyl alcohols and styrenes as surrogates for aldehydes, which bear latent carbonyl functionality. |
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| ISSN: | 0022-3263 1520-6904 |
| DOI: | 10.1021/acs.joc.6b02051 |