Guillain–Barré Syndrome Associated with Zika Virus Infection in Colombia

The Guillain–Barré syndrome has been associated with Zika virus infection. In this report from Colombia, further evidence of the association is provided, as well as further characterization of the associated neurologic syndrome. Zika virus (ZIKV), a mosquito-borne RNA flavivirus, has caused a major outbreak in the Americas that began in 2014. 1 ZIKV infection manifests as a self-limited febrile syndrome associated with rash, conjunctivitis, and arthralgias. 2 – 4 In 2013 and 2014, an increase in the number of cases of the Guillain–Barré syndrome was observed during an outbreak of ZIKV infection in French Polynesia. 5 , 6 Recently, clusters of the Guillain–Barré syndrome and microcephaly have been spatially and temporally related to the current outbreak of ZIKV infection in the Americas. 7 In Colombia, the government reported the first autochthonous case of ZIKV infection in October 2015. . . .