Depletion of intracellular calcium stores is toxic to SH-SY5Y neuronal cells

Inhibiting Ca 2+ uptake by the sarcoendoplasmic reticular Ca 2+-ATPase pump (SERCA) causes release of Ca 2+ from the endoplasmic reticulum (ER), increased cytosolic Ca 2+ ([Ca 2+] cyt) and depletion of ER Ca 2+ stores. These studies were designed to test the effects of SERCA inhibition on neuronal v...

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Veröffentlicht in:	Brain research 2002-01, Vol.924 (2), p.159-166
Hauptverfasser:	Nguyen, Henry N, Wang, Chen, Perry, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Brain Ischemia - metabolism Calcium Calcium - metabolism Calcium-Transporting ATPases - antagonists & inhibitors Cerebral ischemia Cytosol - metabolism Dantrolene - pharmacology Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic reticulum stress Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Humans Hydroquinones - pharmacology Indoles - pharmacology Isolated neuron and nerve. Neuroglia Muscle Relaxants, Central - pharmacology Neuroblastoma Neurons - cytology Neurons - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases Sesquiterpenes - pharmacology Staurosporine - pharmacology Thapsigargin - pharmacology Tumor Cells, Cultured Vertebrates: nervous system and sense organs
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Zusammenfassung:	Inhibiting Ca 2+ uptake by the sarcoendoplasmic reticular Ca 2+-ATPase pump (SERCA) causes release of Ca 2+ from the endoplasmic reticulum (ER), increased cytosolic Ca 2+ ([Ca 2+] cyt) and depletion of ER Ca 2+ stores. These studies were designed to test the effects of SERCA inhibition on neuronal viability, using as a model the human neuroblastoma cell line, SH-SY5Y. Continuous exposure to the SERCA inhibitor thapsigargin (TG) decreased SH-SY5Y viability to
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(01)03229-2