Screening of Chinese and Mongolian herbal drugs for anti-human immunodeficiency virus type 1 (HIV-1) activity

Water and methanol extracts of 30 Chinese and Mongolian medicinal plants were tested for their human immunodeficiency virus type‐1 (HIV‐1) inhibitory activity. Of the 60 extracts, 23 showed anti‐HIV ac‐tivity. Bioassay‐guided fractionation of one of the most active extracts, the methanol extract of...

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Veröffentlicht in:	Phytotherapy research 2002-03, Vol.16 (2), p.186-189
Hauptverfasser:	Ma, Chao-mei, Nakamura, Norio, Miyashiro, Hirotsugu, Hattori, Masao, Komatsu, Katsuko, Kawahata, Takuya, Otake, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - pharmacology Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology anti-HIV-1 activity aromoline Cell Line China Drugs, Chinese Herbal FK-3000 HIV-1 - drug effects Human immunodeficiency virus 1 Humans Inhibitory Concentration 50 Isoquinolines - chemistry Isoquinolines - pharmacology Mongolia Plant Extracts - pharmacology Plant Structures - chemistry Plants, Medicinal - classification Stephania cepharantha Tumor Cells, Cultured
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Zusammenfassung:	Water and methanol extracts of 30 Chinese and Mongolian medicinal plants were tested for their human immunodeficiency virus type‐1 (HIV‐1) inhibitory activity. Of the 60 extracts, 23 showed anti‐HIV ac‐tivity. Bioassay‐guided fractionation of one of the most active extracts, the methanol extract of the root tuber of Stephania cepharantha, led to the isolation of two alkaloids, aromoline and FK‐3000 as potent inhibitory substances. They completely inhibited the cytopathic effects of HIV‐1 on MT‐4 cells at 31.3 and 7.8 μg/mL, respectively. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.922