Maternal–fetal distribution of cadmium in the guinea pig following a low dose inhalation exposure

Pregnant guinea pigs in their last trimester of gestation were exposed by inhalation to cadmium (Cd) chloride level (50 μg/m 3 Cd) for 1 and 5 days. Cd content was evaluated by atomic absorption spectrophotometry. Maternal blood Cd concentration increased by 127 and 223% of control for 1 and 5 days of exposure. Maternal lung Cd concentration increased significantly by 11.66- and by 48.24-fold after 1 and 5 days of treatment, while maternal liver showed an increase of 188 and 227% for 1 and 5 days of exposure. Also, fetal Cd concentration significantly increased in brain (156 and 192%), liver (159 and 174%) and heart (201 and 157%) after 1 and 5 days of exposure, compared to unexposed females. Placental calcium content decreased significantly by 16% of control after 5 days of exposure. These results suggest that low-level inhalation of Cd may pass through the guinea pig placenta and accumulate in fetal brain, liver and heart.