Deleterious Effect of Chlorpyrifos and Cypermethrin on Oxidative Stress Enzymes and Biochemical Indices of Male Albino Rats

This study was carried out to evaluate the effects of chlorpyrifos and cypermethrin, singly and in combination on oxidative stress enzymes and biochemical indices of male albino rats. A total of 35 male albino rats weighing 170-200 g were divided into seven groups (A-G) of five rats each in a Completely Randomized Design. Rats in group A served as the control and received feed and distilled water only. Groups B and C received 5 and 10 mg of chlorpyrifos; groups D and E received 5 and 10 mg of cypermethrin, while groups F and G received 5 and 10 mg of combination (chlorpyrifos+cypermethrin), respectively. On the one hand, result obtained for oxidative stress enzymes revealed that pesticide treatment significantly reduced the levels of superoxide dismutase (SOD), Glutathione Peroxidase (GPx) and Catalase (CAT) activity and increased lipid peroxidation (MDA) level in rats treated with chlorpyrifos only.