Impact of hyperuricaemia on the chronic kidney disease-associated risk factors in a community-based population

Aim Hyperuricaemia is a common finding in subjects with lifestyle related diseases. This study was performed to examine its association with chronic kidney disease (CKD) in relation to other risk factors in a community‐based population. Methods Data from 187 914 participants, excepting CKD stage 5, of the health check‐up were included in this analysis. The association between CKD and its risk factors were examined by a logistic analysis. The association of hyperuricaemia and CKD was also compared in the population without any lifestyle related diseases and the whole population. Results The prevalence of hyperuricaemia was significantly higher in the advanced stage of CKD. The odds ratio of hyperuricaemia was higher than that of other factors for the association with CKD. The odds ratio of many CKD‐associated variables was increased in the advanced stage. Among them, the odds ratio of hyperuricaemia was markedly increased. The prevalence of hyperuricaemia was lower in the population without any lifestyle related diseases than in the whole population in the early stages, the difference of prevalence between the two populations becoming smaller in the advanced stage. Conclusions The association of incident CKD with hyperuricaemia was stronger than with other chronic kidney disease‐risk factors, this association becoming more significant in the advanced stage of chronic kidney disease. Although this result does not indicate the cause and result relationship, the data suggest that hyperuricaemia might not be appropriately treated in this population. Summary at a Glance This cross‐sectional study demonstrated that the association of incident CKD with hyperuricaemia was stronger than with other CKD‐risk factors. This association between hyperuricaemia and CKD was more significant in the advanced stage of CKD.