Different Distribution of HLA Class II Alleles in Anti-Topoisomerase I Autoantibody Responders between Silicosis and Systemic Sclerosis Patients, with a Common Distinct Amino Acid Sequence in the HLA-DQB1 Domain

Autoantibodies against DNA topoisomerase I (anti-topo I) have been reported to be specific to systemic sclerosis (SSc), however, anti-topo I was detected in patients with silicone breast implants, SLE without features of SSc, and rheumatic diseases. We detected anti-topo I positive silicosis patient...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunobiology (1979) 2001-12, Vol.204 (4), p.458-465
Hauptverfasser:	Ueki, Ayako, Isozaki, Yumika, Tomokuni, Akiko, Ueki, Hiroaki, Kusaka, Masayasu, Tanaka, Shinichiro, Otsuki, Takemi, Sakaguchi, Haruko, Hyodoh, Fuminori
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Amino Acids Autoantibodies - immunology DNA Topoisomerases, Type I - immunology Genes, MHC Class II histocompatibility locus HLA HLA-DP Antigens - genetics HLA-DP Antigens - immunology HLA-DP beta-Chains HLA-DQ Antigens - genetics HLA-DQ Antigens - immunology HLA-DQ beta-Chains HLA-DR Antigens - genetics HLA-DR Antigens - immunology HLA-DRB1 Chains Humans Molecular Sequence Data Protein Structure, Tertiary Scleroderma, Systemic - genetics Scleroderma, Systemic - immunology Silicosis - genetics Silicosis - immunology Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Autoantibodies against DNA topoisomerase I (anti-topo I) have been reported to be specific to systemic sclerosis (SSc), however, anti-topo I was detected in patients with silicone breast implants, SLE without features of SSc, and rheumatic diseases. We detected anti-topo I positive silicosis patients without any symptoms of autoimmune diseases.
ISSN:	0171-2985 1878-3279
DOI:	10.1078/0171-2985-00055