Antiproliferative Effects of Mesenchymal Stem Cells and Epithelial Cells on Lymphocytes

We analyzed the interactions between peripheral blood lymphocytes from heterologous donors with mesenchymal stem cells obtained from the tooth pulp and trophoblast. In mixed cultures, proliferation of both lymphocytes and mesenchymal stem cells was suppressed. Similar suppressive effects were observ...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2016-08, Vol.161 (4), p.518-522
Hauptverfasser:	Svirshchevskaya, E. V., Poltavtseva, R. A., Beletskii, I. P., Selezneva, I. I., Sukhikh, G. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cell Biology Cell Communication - physiology Cell Proliferation - physiology Cells, Cultured Coculture Techniques Dental Pulp - cytology Epithelial Cells - cytology Epithelial Cells - physiology Female HEK293 Cells Hep G2 Cells Humans Internal Medicine Killer cells Laboratory Medicine Lymphocytes - cytology Lymphocytes - physiology Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology Microbiology and Immunology Pathology Pregnancy Stem cells Trophoblasts - cytology
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Zusammenfassung:	We analyzed the interactions between peripheral blood lymphocytes from heterologous donors with mesenchymal stem cells obtained from the tooth pulp and trophoblast. In mixed cultures, proliferation of both lymphocytes and mesenchymal stem cells was suppressed. Similar suppressive effects were observed in lymphocyte cultures mixed with epithelial cells (hepatocytes HeG2 and renal epithelial cells HEK293). This suppression can be determined by impairment of normal adhesion contacts between cells of different origin.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-016-3451-x