Characterization of two novel sialyl N-acetyllactosaminyl nucleotides separated from ovine colostrum

The milk/colostrum of some mammalian species is known to contain sugar nucleotides including uridine diphosphate (UDP) oligosaccharides in addition to lactose and milk oligosaccharides, but the detailed structures of these UDP oligosaccharides have not so far been clarified. In this study we isolate...

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Veröffentlicht in:	Glycoconjugate journal 2016-10, Vol.33 (5), p.789-796
Hauptverfasser:	Sasaki, Masashi, Nakamura, Tadashi, Hirayama, Kentaro, Fukuda, Kenji, Saito, Tadao, Urashima, Tadasu, Asakuma, Sadaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Colostrum - chemistry Colostrum - metabolism Female Hogs Life Sciences Magnetic Resonance Spectroscopy Milk Original Article Pathology Sheep Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Sugar Uridine Diphosphate N-Acetylgalactosamine - analysis Uridine Diphosphate N-Acetylgalactosamine - metabolism
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Zusammenfassung:	The milk/colostrum of some mammalian species is known to contain sugar nucleotides including uridine diphosphate (UDP) oligosaccharides in addition to lactose and milk oligosaccharides, but the detailed structures of these UDP oligosaccharides have not so far been clarified. In this study we isolated two UDP-sialyl N -acetyllactosamines from ovine colostrum and characterized them using 1 H-NMR and MALDI-TOFMS spectroscopies. Their structures were found to be Neu5Gc(α2–3)Gal(β1–4)GlcNAcα1-UDP and Neu5Gc(α2–6)Gal(β1–4)GlcNAcα1-UDP.
ISSN:	0282-0080 1573-4986
DOI:	10.1007/s10719-016-9672-4