Experimental Evaluation of Biodegradable Film Compositions Based on Gelatin with Colchicine
Biodegradable film compositions based on natural biopolymer gelatin with immobilized colchicine were prepared and their efficiency in prevention of the adhesion process in the pericardium was evaluated on rabbit model of postoperative pericarditis. The use of gelatin-based biodegradable film composi...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2016-07, Vol.161 (3), p.414-418 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Bokeriya, L. A. Bokeriya, O. L. Sivtsev, V. S. Novikova, S. P. Salokhedinova, R. R. Nikolashina, L. N. Samsonova, N. N. Gorodkov, A. Yu Serov, R. A. |
| description | Biodegradable film compositions based on natural biopolymer gelatin with immobilized colchicine were prepared and their efficiency in prevention of the adhesion process in the pericardium was evaluated on rabbit model of postoperative pericarditis. The use of gelatin-based biodegradable film compositions significantly reduced the intensity of adhesion formation in the pericardial cavity, while immobilization of anti-inflammatory drug colchicine amplified their anti-adhesion activity. |
| doi_str_mv | 10.1007/s10517-016-3428-9 |
| format | Article |
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A.</creatorcontrib><creatorcontrib>Bokeriya, O. L.</creatorcontrib><creatorcontrib>Sivtsev, V. S.</creatorcontrib><creatorcontrib>Novikova, S. P.</creatorcontrib><creatorcontrib>Salokhedinova, R. R.</creatorcontrib><creatorcontrib>Nikolashina, L. N.</creatorcontrib><creatorcontrib>Samsonova, N. N.</creatorcontrib><creatorcontrib>Gorodkov, A. Yu</creatorcontrib><creatorcontrib>Serov, R. A.</creatorcontrib><title>Experimental Evaluation of Biodegradable Film Compositions Based on Gelatin with Colchicine</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Biodegradable film compositions based on natural biopolymer gelatin with immobilized colchicine were prepared and their efficiency in prevention of the adhesion process in the pericardium was evaluated on rabbit model of postoperative pericarditis. The use of gelatin-based biodegradable film compositions significantly reduced the intensity of adhesion formation in the pericardial cavity, while immobilization of anti-inflammatory drug colchicine amplified their anti-adhesion activity.</description><subject>Analysis</subject><subject>Animals</subject><subject>Biodegradation, Environmental</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Colchicine</subject><subject>Colchicine - chemistry</subject><subject>Female</subject><subject>Gelatin - adverse effects</subject><subject>Gelatin - chemistry</subject><subject>Health aspects</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Pathology</subject><subject>Pericardium - cytology</subject><subject>Pericardium - drug effects</subject><subject>Rabbits</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk9v1DAQxSMEokvhA3BBkZBQLyke_4t9bFfbglSJC5w4WI4z2XXlxEucFPj2ddhStQgk5INl-_eeZsavKF4DOQVC6vcJiIC6IiArxqmq9JNiBaJmlaIUnhYrkqGKK6WOihcpXS9HIuF5cURrriVhclV83fzY4-h7HCYbys2NDbOdfBzK2JXnPra4HW1rm4DlhQ99uY79Pia_EKk8twnbMrOXGLJoKL_7aZeR4Hbe-QFfFs86GxK-utuPiy8Xm8_rD9XVp8uP67OryuVap0rWktYUtXYttNwCdQwbXTdCcgYEWEc1oQxa7YQUgosWsOOSiZow6BrVsePi5OC7H-O3GdNkep8chmAHjHMyoGitgQrB_gMFLiWjlGb07R_odZzHITeSKUmUZiyP8J7a2oDGD12cRusWU3PGtRKKca4zdfoXKq8We-_igJ3P948E7x4IdmjDtEsxzL8G_xiEA-jGmNKIndnn37TjTwPELCExh5CYHBKzhMQsmjd3nc1Nj-294ncqMkAPQMpPwxbHB63_0_UWbgLCbw</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Bokeriya, L. 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A. ; Bokeriya, O. L. ; Sivtsev, V. S. ; Novikova, S. P. ; Salokhedinova, R. R. ; Nikolashina, L. N. ; Samsonova, N. N. ; Gorodkov, A. Yu ; Serov, R. 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The use of gelatin-based biodegradable film compositions significantly reduced the intensity of adhesion formation in the pericardial cavity, while immobilization of anti-inflammatory drug colchicine amplified their anti-adhesion activity.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27496036</pmid><doi>10.1007/s10517-016-3428-9</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2016-07, Vol.161 (3), p.414-418 |
| issn | 0007-4888 1573-8221 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1827912553 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Analysis Animals Biodegradation, Environmental Biomedical and Life Sciences Biomedicine Cell Biology Colchicine Colchicine - chemistry Female Gelatin - adverse effects Gelatin - chemistry Health aspects Internal Medicine Laboratory Medicine Male Pathology Pericardium - cytology Pericardium - drug effects Rabbits |
| title | Experimental Evaluation of Biodegradable Film Compositions Based on Gelatin with Colchicine |
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