Experimental Evaluation of Biodegradable Film Compositions Based on Gelatin with Colchicine

Experimental Evaluation of Biodegradable Film Compositions Based on Gelatin with Colchicine

Biodegradable film compositions based on natural biopolymer gelatin with immobilized colchicine were prepared and their efficiency in prevention of the adhesion process in the pericardium was evaluated on rabbit model of postoperative pericarditis. The use of gelatin-based biodegradable film composi...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2016-07, Vol.161 (3), p.414-418
Hauptverfasser: Bokeriya, L. A., Bokeriya, O. L., Sivtsev, V. S., Novikova, S. P., Salokhedinova, R. R., Nikolashina, L. N., Samsonova, N. N., Gorodkov, A. Yu, Serov, R. A.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Animals
Biodegradation, Environmental
Biomedical and Life Sciences
Biomedicine
Cell Biology
Colchicine
Colchicine - chemistry
Female
Gelatin - adverse effects
Gelatin - chemistry
Health aspects
Internal Medicine
Laboratory Medicine
Male
Pathology
Pericardium - cytology
Pericardium - drug effects
Rabbits
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Zusammenfassung:Biodegradable film compositions based on natural biopolymer gelatin with immobilized colchicine were prepared and their efficiency in prevention of the adhesion process in the pericardium was evaluated on rabbit model of postoperative pericarditis. The use of gelatin-based biodegradable film compositions significantly reduced the intensity of adhesion formation in the pericardial cavity, while immobilization of anti-inflammatory drug colchicine amplified their anti-adhesion activity.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3428-9