Experimental Evaluation of Biodegradable Film Compositions Based on Gelatin with Colchicine

Biodegradable film compositions based on natural biopolymer gelatin with immobilized colchicine were prepared and their efficiency in prevention of the adhesion process in the pericardium was evaluated on rabbit model of postoperative pericarditis. The use of gelatin-based biodegradable film composi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2016-07, Vol.161 (3), p.414-418
Hauptverfasser:	Bokeriya, L. A., Bokeriya, O. L., Sivtsev, V. S., Novikova, S. P., Salokhedinova, R. R., Nikolashina, L. N., Samsonova, N. N., Gorodkov, A. Yu, Serov, R. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biodegradation, Environmental Biomedical and Life Sciences Biomedicine Cell Biology Colchicine Colchicine - chemistry Female Gelatin - adverse effects Gelatin - chemistry Health aspects Internal Medicine Laboratory Medicine Male Pathology Pericardium - cytology Pericardium - drug effects Rabbits
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Biodegradable film compositions based on natural biopolymer gelatin with immobilized colchicine were prepared and their efficiency in prevention of the adhesion process in the pericardium was evaluated on rabbit model of postoperative pericarditis. The use of gelatin-based biodegradable film compositions significantly reduced the intensity of adhesion formation in the pericardial cavity, while immobilization of anti-inflammatory drug colchicine amplified their anti-adhesion activity.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-016-3428-9