A second estrogen receptor from Japanese lamprey ( Lethenteron japonicum ) does not have activities for estrogen binding and transcription

A second estrogen receptor from Japanese lamprey ( Lethenteron japonicum ) does not have activities for estrogen binding and transcription

Highlights • Two distinct ER subtypes, Esr1a and Esr1b were isolated from Japanese lamprey. • 17β-estradiol and other estrogens are transcriptional activators of lamprey Esr1a. • Lamprey Esr1a has constitutive activity that is regulated by the A/B domain. • Lamprey Esr1b does not bind 17β-estradiol....

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Veröffentlicht in:General and comparative endocrinology 2016-09, Vol.236, p.105-114
Hauptverfasser: Katsu, Yoshinao, Cziko, Paul A, Chandsawangbhuwana, Charlie, Thornton, Joseph W, Sato, Rui, Oka, Koari, Takei, Yoshio, Baker, Michael E, Iguchi, Taisen
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Endocrinology & Metabolism
Estrogen receptor
Evolution
Evolution, Molecular
Humans
Japan
Lamprey
Lampreys - genetics
Lethenteron japonicum
Petromyzontidae
Phylogeny
Receptors, Estrogen - genetics
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Beschreibung
Zusammenfassung:Highlights • Two distinct ER subtypes, Esr1a and Esr1b were isolated from Japanese lamprey. • 17β-estradiol and other estrogens are transcriptional activators of lamprey Esr1a. • Lamprey Esr1a has constitutive activity that is regulated by the A/B domain. • Lamprey Esr1b does not bind 17β-estradiol.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2016.07.014