Tanshinone IIA sensitizes oral squamous cell carcinoma to radiation due to an enhanced autophagy

Highlights • The radiosensitizing effect of Tanshinone IIA on human oral squamous cell carcinoma was investigated. • The mechanisms rely on an enhanced reactive oxygen species generation and autophagy. • Tanshinone IIA may be a potential active components used to treat oral squamous cell carcinoma....

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Veröffentlicht in:	Environmental toxicology and pharmacology 2016-09, Vol.46, p.264-269
Hauptverfasser:	Ding, Lijuan, Wang, Shudong, Qu, Xiaozhang, Wang, Jiafeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis - radiation effects Autophagy Autophagy - drug effects Autophagy - radiation effects Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Cell Line, Tumor Cell Survival - drug effects Cell Survival - radiation effects Diterpenes, Abietane - administration & dosage Diterpenes, Abietane - isolation & purification Diterpenes, Abietane - pharmacology Emergency Flow Cytometry Gamma Rays Humans Mouth Neoplasms - pathology Mouth Neoplasms - radiotherapy Plant Roots - chemistry Radiation Radiation-Sensitizing Agents - administration & dosage Radiation-Sensitizing Agents - isolation & purification Radiation-Sensitizing Agents - pharmacology Salvia miltiorrhiza Salvia miltiorrhiza - chemistry SCC090 Tanshinone IIA
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Zusammenfassung:	Highlights • The radiosensitizing effect of Tanshinone IIA on human oral squamous cell carcinoma was investigated. • The mechanisms rely on an enhanced reactive oxygen species generation and autophagy. • Tanshinone IIA may be a potential active components used to treat oral squamous cell carcinoma.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2016.07.021