Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: Roles of PERK/eIF2α signaling pathway

Highlights • Long-term ALA supplement can ameliorate age-related cognitive impairment. • Long-term ALA supplement decreases AD-like pathology during natural aging. • ALA plays neuroprotection via suppressing the PERK/eIF2α branch of UPR signaling.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-10, Vol.57, p.314-325
Hauptverfasser:	Gao, Hui, Yan, Peipei, Zhang, Shun, Nie, Shuke, Huang, Fenghong, Han, Hao, Deng, Qianchun, Huang, Qingde, Yang, Wei, Wu, Hailei, Yao, Ping, Ye, Keqiang, Xu, Jiqu, Liu, Liegang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - drug effects Allergy and Immunology alpha-Linolenic Acid - administration & dosage alpha-Linolenic Acid - pharmacology Animals Disease Models, Animal eIF-2 Kinase - drug effects Endoplasmic reticulum stress Female Learning and memory Memory Disorders - prevention & control Psychiatry Rats Rats, Sprague-Dawley Signal Transduction - drug effects Unfold protein response α-Linolenic acid
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Beschreibung
Zusammenfassung:	Highlights • Long-term ALA supplement can ameliorate age-related cognitive impairment. • Long-term ALA supplement decreases AD-like pathology during natural aging. • ALA plays neuroprotection via suppressing the PERK/eIF2α branch of UPR signaling.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.09.012