Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer
Highlights • Cystine starvation or glutamine excess leads to ferroptosis in head and neck cancer (HNC) cells. • Inhibition of cystine/glutamate antiporter (SLC7A11) induces ferroptosis in cisplatin-resistant HNC cells. • Silencing of the SLC7A11 gene increases the cisplatin sensitivity of resistant...
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| Veröffentlicht in: | Cancer letters 2016-10, Vol.381 (1), p.96-103 |
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| container_title | Cancer letters |
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| creator | Roh, Jong-Lyel Kim, Eun Hye Jang, Hye Jin Park, Jin Young Shin, Dai Ha |
| description | Highlights • Cystine starvation or glutamine excess leads to ferroptosis in head and neck cancer (HNC) cells. • Inhibition of cystine/glutamate antiporter (SLC7A11) induces ferroptosis in cisplatin-resistant HNC cells. • Silencing of the SLC7A11 gene increases the cisplatin sensitivity of resistant HNC cells. • Sulfasalazine sensitizes cisplatin-resistant HNC cells to cisplatin in vitro and vivo. |
| doi_str_mv | 10.1016/j.canlet.2016.07.035 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 10, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-5028842a4b14490042f195eef47e845ed82307144211001529e6fbcb6f2c85563</citedby><cites>FETCH-LOGICAL-c544t-5028842a4b14490042f195eef47e845ed82307144211001529e6fbcb6f2c85563</cites><orcidid>0000-0002-1537-1977</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2016.07.035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27477897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roh, Jong-Lyel</creatorcontrib><creatorcontrib>Kim, Eun Hye</creatorcontrib><creatorcontrib>Jang, Hye Jin</creatorcontrib><creatorcontrib>Park, Jin Young</creatorcontrib><creatorcontrib>Shin, Dai Ha</creatorcontrib><title>Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights • Cystine starvation or glutamine excess leads to ferroptosis in head and neck cancer (HNC) cells. • Inhibition of cystine/glutamate antiporter (SLC7A11) induces ferroptosis in cisplatin-resistant HNC cells. • Silencing of the SLC7A11 gene increases the cisplatin sensitivity of resistant HNC cells. • Sulfasalazine sensitizes cisplatin-resistant HNC cells to cisplatin in vitro and vivo.</description><subject>Amino Acid Transport System y+ - antagonists & inhibitors</subject><subject>Amino Acid Transport System y+ - genetics</subject><subject>Amino Acid Transport System y+ - metabolism</subject><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Cancer therapies</subject><subject>Cell death</subject><subject>Cell Death - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Chemotherapy</subject><subject>Cisplatin - pharmacology</subject><subject>Cisplatin resistance</subject><subject>Conflicts of interest</subject><subject>Cystine - metabolism</subject><subject>Cystine/glutamate antiporter</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Resistance, Neoplasm - drug effects</subject><subject>Ferroptosis</subject><subject>Glutamine - metabolism</subject><subject>Glutathione - metabolism</subject><subject>Head & neck cancer</subject><subject>Head and neck cancer</subject><subject>Head and Neck Neoplasms - drug therapy</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Head and Neck Neoplasms - metabolism</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Life sciences</subject><subject>Lipid reactive oxygen species</subject><subject>Male</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Piperazines - pharmacology</subject><subject>Radiation therapy</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>RNA Interference</subject><subject>Sulfasalazine - pharmacology</subject><subject>Transfection</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk9v1DAQxS0EotvCN0DIEhcuCWPHjp0LEqoKrVSJA3C2vM6Eepu1F9up1G-PwxaQeoGT__3mWW_eEPKKQcuA9e92rbNhxtLyempBtdDJJ2TDtOKNGjQ8JRvoQDSd7uQJOc15BwBSKPmcnHAllNKD2hBzFcbFFR8DjROdMKV4KLF4Rx3OMx3Rlhs6xUTjHSYX9z58p87nw2yLDzRh9rnY4HCtvkE7UhtGGtDdUrdepxfk2WTnjC8f1jPy7ePF1_PL5vrzp6vzD9eNk0KURgLXWnArtkyIAUDwiQ0ScRIKtZA4at6Bqm-cMQAm-YD9tHXbfuJOS9l3Z-TtUfeQ4o8FczF7n1cLNmBcsmGaV8NSafYfKNOdAAVQ0TeP0F1cUqhGflGy6smVEkfKpZhzwskckt_bdG8YmDUrszPHrMyalQFlala17PWD-LLd4_in6Hc4FXh_BLA27s5jMtl5rF0dfUJXzBj9v354LOBmH7yz8y3eY_7rxWRuwHxZ52UdF9bXjRS8-wl6VrmW</recordid><startdate>20161010</startdate><enddate>20161010</enddate><creator>Roh, Jong-Lyel</creator><creator>Kim, Eun Hye</creator><creator>Jang, Hye Jin</creator><creator>Park, Jin Young</creator><creator>Shin, Dai Ha</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1537-1977</orcidid></search><sort><creationdate>20161010</creationdate><title>Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer</title><author>Roh, Jong-Lyel ; Kim, Eun Hye ; Jang, Hye Jin ; Park, Jin Young ; Shin, Dai Ha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-5028842a4b14490042f195eef47e845ed82307144211001529e6fbcb6f2c85563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Amino Acid Transport System y+ - antagonists & inhibitors</topic><topic>Amino Acid Transport System y+ - genetics</topic><topic>Amino Acid Transport System y+ - metabolism</topic><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Cancer therapies</topic><topic>Cell death</topic><topic>Cell Death - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Chemotherapy</topic><topic>Cisplatin - pharmacology</topic><topic>Cisplatin resistance</topic><topic>Conflicts of interest</topic><topic>Cystine - metabolism</topic><topic>Cystine/glutamate antiporter</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA damage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Resistance, Neoplasm - drug effects</topic><topic>Ferroptosis</topic><topic>Glutamine - metabolism</topic><topic>Glutathione - metabolism</topic><topic>Head & neck cancer</topic><topic>Head and neck cancer</topic><topic>Head and Neck Neoplasms - drug therapy</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Head and Neck Neoplasms - metabolism</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Life sciences</topic><topic>Lipid reactive oxygen species</topic><topic>Male</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Piperazines - pharmacology</topic><topic>Radiation therapy</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>RNA Interference</topic><topic>Sulfasalazine - pharmacology</topic><topic>Transfection</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roh, Jong-Lyel</creatorcontrib><creatorcontrib>Kim, Eun Hye</creatorcontrib><creatorcontrib>Jang, Hye Jin</creatorcontrib><creatorcontrib>Park, Jin Young</creatorcontrib><creatorcontrib>Shin, Dai Ha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - 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| ispartof | Cancer letters, 2016-10, Vol.381 (1), p.96-103 |
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| subjects | Amino Acid Transport System y+ - antagonists & inhibitors Amino Acid Transport System y+ - genetics Amino Acid Transport System y+ - metabolism Animals Antineoplastic Agents - pharmacology Apoptosis Cancer therapies Cell death Cell Death - drug effects Cell Line, Tumor Chemotherapy Cisplatin - pharmacology Cisplatin resistance Conflicts of interest Cystine - metabolism Cystine/glutamate antiporter Deoxyribonucleic acid DNA DNA damage Dose-Response Relationship, Drug Drug Resistance, Neoplasm - drug effects Ferroptosis Glutamine - metabolism Glutathione - metabolism Head & neck cancer Head and neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Hematology, Oncology and Palliative Medicine Humans Life sciences Lipid reactive oxygen species Male Mice, Inbred BALB C Mice, Nude Piperazines - pharmacology Radiation therapy Reactive Oxygen Species - metabolism RNA Interference Sulfasalazine - pharmacology Transfection Xenograft Model Antitumor Assays |
| title | Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer |
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