Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer

Highlights • Cystine starvation or glutamine excess leads to ferroptosis in head and neck cancer (HNC) cells. • Inhibition of cystine/glutamate antiporter (SLC7A11) induces ferroptosis in cisplatin-resistant HNC cells. • Silencing of the SLC7A11 gene increases the cisplatin sensitivity of resistant...

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Veröffentlicht in:	Cancer letters 2016-10, Vol.381 (1), p.96-103
Hauptverfasser:	Roh, Jong-Lyel, Kim, Eun Hye, Jang, Hye Jin, Park, Jin Young, Shin, Dai Ha
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System y+ - antagonists & inhibitors Amino Acid Transport System y+ - genetics Amino Acid Transport System y+ - metabolism Animals Antineoplastic Agents - pharmacology Apoptosis Cancer therapies Cell death Cell Death - drug effects Cell Line, Tumor Chemotherapy Cisplatin - pharmacology Cisplatin resistance Conflicts of interest Cystine - metabolism Cystine/glutamate antiporter Deoxyribonucleic acid DNA DNA damage Dose-Response Relationship, Drug Drug Resistance, Neoplasm - drug effects Ferroptosis Glutamine - metabolism Glutathione - metabolism Head & neck cancer Head and neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Hematology, Oncology and Palliative Medicine Humans Life sciences Lipid reactive oxygen species Male Mice, Inbred BALB C Mice, Nude Piperazines - pharmacology Radiation therapy Reactive Oxygen Species - metabolism RNA Interference Sulfasalazine - pharmacology Transfection Xenograft Model Antitumor Assays
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Zusammenfassung:	Highlights • Cystine starvation or glutamine excess leads to ferroptosis in head and neck cancer (HNC) cells. • Inhibition of cystine/glutamate antiporter (SLC7A11) induces ferroptosis in cisplatin-resistant HNC cells. • Silencing of the SLC7A11 gene increases the cisplatin sensitivity of resistant HNC cells. • Sulfasalazine sensitizes cisplatin-resistant HNC cells to cisplatin in vitro and vivo.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.07.035