Total synthesis of fellutamides, lipopeptide proteasome inhibitors. More sustainable peptide bond formation
Solution-phase syntheses of three bioactive natural products of mixed polypeptidepolyketide biogenesis, fellutamides A, B, and C, have been achieved. Three peptide bonds are generated without the use of coupling reagents in each synthesis of the fellutamides, which act against proteasomes. Solution-...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2016-09, Vol.14 (35), p.8367-8375 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Pirrung, Michael C Zhang, Fa Ambadi, Sudhakar Gangadhara Rao, Y |
| description | Solution-phase syntheses of three bioactive natural products of mixed polypeptidepolyketide biogenesis, fellutamides A, B, and C, have been achieved. Three peptide bonds are generated without the use of coupling reagents in each synthesis of the fellutamides, which act against proteasomes.
Solution-phase syntheses of three bioactive natural products of mixed polypeptidepolyketide biogenesis, fellutamides A, B, and C, have been achieved. |
| doi_str_mv | 10.1039/c6ob01233g |
| format | Article |
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| ispartof | Organic & biomolecular chemistry, 2016-09, Vol.14 (35), p.8367-8375 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Biological Products - chemistry Chemistry Techniques, Synthetic - methods Lipopeptides - chemical synthesis Molecular Structure Oligopeptides - chemical synthesis Proteasome Inhibitors - chemical synthesis Solutions - chemistry |
| title | Total synthesis of fellutamides, lipopeptide proteasome inhibitors. More sustainable peptide bond formation |
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