Total synthesis of fellutamides, lipopeptide proteasome inhibitors. More sustainable peptide bond formation

Total synthesis of fellutamides, lipopeptide proteasome inhibitors. More sustainable peptide bond formation

Solution-phase syntheses of three bioactive natural products of mixed polypeptidepolyketide biogenesis, fellutamides A, B, and C, have been achieved. Three peptide bonds are generated without the use of coupling reagents in each synthesis of the fellutamides, which act against proteasomes. Solution-...

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Veröffentlicht in:Organic & biomolecular chemistry 2016-09, Vol.14 (35), p.8367-8375
Hauptverfasser: Pirrung, Michael C, Zhang, Fa, Ambadi, Sudhakar, Gangadhara Rao, Y
Format: Artikel
Sprache:eng
Schlagworte:
Biological Products - chemistry
Chemistry Techniques, Synthetic - methods
Lipopeptides - chemical synthesis
Molecular Structure
Oligopeptides - chemical synthesis
Proteasome Inhibitors - chemical synthesis
Solutions - chemistry
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Zusammenfassung:Solution-phase syntheses of three bioactive natural products of mixed polypeptidepolyketide biogenesis, fellutamides A, B, and C, have been achieved. Three peptide bonds are generated without the use of coupling reagents in each synthesis of the fellutamides, which act against proteasomes. Solution-phase syntheses of three bioactive natural products of mixed polypeptidepolyketide biogenesis, fellutamides A, B, and C, have been achieved.
ISSN:1477-0520
1477-0539
DOI:10.1039/c6ob01233g