Reply to letter to the editor by Kintur Sanghvi MD; Allen McGrew DO; Kiran Hegde BE, MBA

[...]the overlapping circumferential coverage for 4 electrodes will be greater than 100% (Fig. 3) across the range from 3 to 8mm. [...]despite electrode spacing at intervals less than 90° in smaller-diameter vessels, the resulting lesion pattern still encompasses a full 4-quadrant circumferential treatment. The ongoing SPYRAL HTN Global Clinical Trial Program5 will also provide key comparisons of device safety and efficacy between treated and sham control subjects both on and off antihypertensive medication.