miR-187-3p inhibits the metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting S100A4

Highlights of this study • MiR-187-3p is significantly down-regulated in HCC, and is correlated with adverse clinical features and poor prognosis of HCC patients. • MiR-187-3p can inhibit the metastasis of HCC cells by regulating EMT phenotype. • S100A4 is a direct downstream target of miR-187-3p, a...

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Veröffentlicht in:	Cancer letters 2016-10, Vol.381 (2), p.380-390
Hauptverfasser:	Dou, Changwei, MD, Liu, Zhikui, MD, Xu, Meng, MD, Jia, Yuli, MD, Wang, Yufeng, MD, Li, Qing, MD, Yang, Wei, PhD, MD, Zheng, Xin, PhD, MD, Tu, Kangsheng, PhD, MD, Liu, Qingguang, PhD, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast cancer Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - secondary Carcinoma, Hepatocellular - surgery Cell Movement Conflicts of interest Disease Progression Disease-Free Survival EMT Epithelial-Mesenchymal Transition Female Gene expression Gene Expression Regulation, Neoplastic Genotype & phenotype Hematology, Oncology and Palliative Medicine Hep G2 Cells Hepatocellular carcinoma Humans Hypoxia Kaplan-Meier Estimate Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - surgery Lymphoma Male Medical prognosis Metastasis Mice, Nude MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR-187-3p Neoplasm Invasiveness RNA Interference S100 Calcium-Binding Protein A4 - genetics S100 Calcium-Binding Protein A4 - metabolism S100A4 Signal Transduction Time Factors Transfection Tumor Hypoxia Tumor Microenvironment Wound healing
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Zusammenfassung:	Highlights of this study • MiR-187-3p is significantly down-regulated in HCC, and is correlated with adverse clinical features and poor prognosis of HCC patients. • MiR-187-3p can inhibit the metastasis of HCC cells by regulating EMT phenotype. • S100A4 is a direct downstream target of miR-187-3p, and mediated the biological function of miR-187-3p in HCC. • MiR-187-3p can be down-regulated by hypoxia, and is involved in the promoting effects of hypoxia on the metastasis and EMT of HCC cells
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.08.011