Acute intoxication with orphenadrine and clozapine

Acute intoxication with orphenadrine and clozapine

This report describes a fatal intoxication with two different drugs: clozapine and orphenadrine. A 38-year-old man was found dead in the bedroom of his residence. Near the body were found various empty pharmaceutical boxes, employed in schizophrenic therapy, two of them containing clozapine and orph...

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Veröffentlicht in:Forensic science international 2001-11, Vol.123 (1), p.13-16
Hauptverfasser: Fucci, Nadia, Romano, Barbara, Zirilli, Arianna
Format: Artikel
Sprache:eng
Schlagworte:
Acute intoxication
Adult
Antipsychotic Agents - blood
Antipsychotic Agents - poisoning
Antipsychotic Agents - urine
Antipsychotics
Autopsies
Biological and medical sciences
Clozapine
Clozapine - blood
Clozapine - poisoning
Clozapine - urine
Drug intoxications. Doping
Fatalities
Forensic Medicine
Forensic sciences
Gas chromatography
Gas Chromatography-Mass Spectrometry
Heart
Humans
Intoxication
Liquid-liquid extraction
Male
Mass spectrometry
Mass spectroscopy
Medical sciences
Muscarinic Antagonists - blood
Muscarinic Antagonists - poisoning
Muscarinic Antagonists - urine
Orphenadrine
Orphenadrine - blood
Orphenadrine - poisoning
Orphenadrine - urine
Pharmacology. Drug treatments
Schizophrenia
Urine
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Beschreibung
Zusammenfassung:This report describes a fatal intoxication with two different drugs: clozapine and orphenadrine. A 38-year-old man was found dead in the bedroom of his residence. Near the body were found various empty pharmaceutical boxes, employed in schizophrenic therapy, two of them containing clozapine and orphenadrine. High concentrations of clozapine and orphenadrine detected in blood, urine and gastric content were related to death. These compounds were identified and quantitated by liquid–liquid extraction followed by gas chromatographic/mass spectrometry (GC/MS) analysis.
ISSN:0379-0738
1872-6283
DOI:10.1016/S0379-0738(01)00509-6