Altered expression of CD63 and exosomes in scleroderma dermal fibroblasts

Highlights • Exosome levels in SSc skin were up-regulated. • Increased exosomes in cultured media of SSc fibroblasts stimulated type I collagen expression levels in NS fibroblasts. • Treatment with serum-derived exosomes accelerated skin ulcer healing in mice.

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Veröffentlicht in:Journal of dermatological science 2016-10, Vol.84 (1), p.30-39
Hauptverfasser: Nakamura, Kayo, Jinnin, Masatoshi, Harada, Miho, Kudo, Hideo, Nakayama, Wakana, Inoue, Kuniko, Ogata, Aki, Kajihara, Ikko, Fukushima, Satoshi, Ihn, Hironobu
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Sprache:eng
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Zusammenfassung:Highlights • Exosome levels in SSc skin were up-regulated. • Increased exosomes in cultured media of SSc fibroblasts stimulated type I collagen expression levels in NS fibroblasts. • Treatment with serum-derived exosomes accelerated skin ulcer healing in mice.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2016.06.013