Altered expression of CD63 and exosomes in scleroderma dermal fibroblasts

Highlights • Exosome levels in SSc skin were up-regulated. • Increased exosomes in cultured media of SSc fibroblasts stimulated type I collagen expression levels in NS fibroblasts. • Treatment with serum-derived exosomes accelerated skin ulcer healing in mice.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of dermatological science 2016-10, Vol.84 (1), p.30-39
Hauptverfasser:	Nakamura, Kayo, Jinnin, Masatoshi, Harada, Miho, Kudo, Hideo, Nakayama, Wakana, Inoue, Kuniko, Ogata, Aki, Kajihara, Ikko, Fukushima, Satoshi, Ihn, Hironobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopsy CD63 Cell Communication Collagen Type I - chemistry Culture Media Dermatology Exosomes Exosomes - metabolism Fibroblasts - metabolism Gene Expression Profiling Gene Expression Regulation Humans Immunohistochemistry Lipids - chemistry Male Mice Mice, Inbred BALB C MicroRNAs - metabolism Middle Aged Real-Time Polymerase Chain Reaction Scleroderma, Systemic - metabolism Skin - metabolism Skin Ulcer - metabolism Systemic sclerosis Tetraspanin 28 - metabolism Tetraspanin 30 - metabolism Tetraspanin-29 - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Exosome levels in SSc skin were up-regulated. • Increased exosomes in cultured media of SSc fibroblasts stimulated type I collagen expression levels in NS fibroblasts. • Treatment with serum-derived exosomes accelerated skin ulcer healing in mice.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2016.06.013