The potential for repositioning antithyroid agents as antiasthma drugs

Next, we used mice deficient in each of the 3 peroxidases (Mpo, Epx, and Lpo) to determine which peroxidase dominantly contributes to the setting of allergic airway inflammation. Because Lpo-deficient mice were not available, we generated Lpo-deficient animals on a BALB/c background in preparation for these studies (see Fig E4 in this article's Online Repository at www.jacionline.org). Age (y) Sex Feno (ppb) Treatment IgE (IU/mL) FEV1 (%) Eosinophil (/μL) LPO mRNA (copy number/μg) Heme peroxidase activity (ng/mL) 1 61 M 44 FP200 μg/d 528 98.0 33 11,600 809 2 35 M 134 FP500 μg/d 82 53.3 286 4,100 2,792 3 36 M 52 FP500 μg/d 2657 96.8 659 130 367 4 38 M 34 FP400 μg/d 1286 63.0 296 640 8,317 5 40 M 34 FP200 μg/d 293 96.3 280 16,400 567 6 36 F 30 BUD200 μg/d 572 82.8 341 76,500 483 7 65 M 39 FP200 μg/d 909 48.1 252 12,300 392 8 48 M 25 FP400 μg/d 88 65.9 391 ND 550 9 39 M 62 FP100 μg/d 134 104.8 293 ND 6,083 10 40 F 46 BUD400 μg/d 190 59.1 179 960 967 Table E1 Clinical backgrounds, LPO expression, and heme peroxidase activity in patients with asthma BUD, Budesonide; F, female; Feno, fractional exhaled nitric oxide; FP, fluticasone propionate; M, male; ND, not determined.