Cardiorespiratory activity of C-terminal pentapeptide of substance P in anaesthetized rats

Highlights • Cardiovascular and respiratory effects of substance P and AWL2077 were compared. • AWL2077 affected respiratory variables less than substance P. • Fall in arterial blood pressure was of equal intensity for both peptides. • Involvement of lung vagi referred to respiratory timing.

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Bibliographische Detailangaben
Veröffentlicht in:	Respiratory physiology & neurobiology 2016-11, Vol.233, p.7-13
Hauptverfasser:	Wojciechowski, Piotr, Szereda-Przestaszewska, Małgorzata, Lipkowski, Andrzej Wojciech
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Anesthesia Animals Blood Pressure - drug effects Cardiovascular effects Heart Rate - drug effects Male Medical Education Peptide Fragments - pharmacology Pulmonary/Respiratory Rats Rats, Wistar Respiration Respiration - drug effects Respiratory Rate - drug effects Substance P Substance P - chemistry Substance P - pharmacology Substance P7–11 (AWL2077) Tidal Volume - drug effects Time Factors Vagotomy
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Beschreibung
Zusammenfassung:	Highlights • Cardiovascular and respiratory effects of substance P and AWL2077 were compared. • AWL2077 affected respiratory variables less than substance P. • Fall in arterial blood pressure was of equal intensity for both peptides. • Involvement of lung vagi referred to respiratory timing.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2016.07.006