Next-generation sequencing identifies micro-RNA–based biomarker panel for Kawasaki disease

Because males have a higher KD incidence rate than do females, we further investigated whether the 10 miRNAs are significantly differentially expressed between male and female subjects, causing bias when served as a disease biomarker. The expressions of the remaining 9 biomarker miRNAs were not sex...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2016-10, Vol.138 (4), p.1227-1230
Hauptverfasser:	Kuo, Ho-Chang, MD, PhD, Hsieh, Kai-Sheng, MD, Ming-Huey Guo, Mindy, MD, Weng, Ken-Pen, MD, Ger, Luo-Ping, PhD, Chan, Wen-Ching, PhD, Li, Sung-Chou, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Biomarkers Case-Control Studies Child, Preschool Classification Coronary vessels Early Diagnosis Female Fever Genetic Markers High-Throughput Nucleotide Sequencing Humans Immunoglobulins Infections Kawasaki disease Male Males MicroRNAs - blood MicroRNAs - genetics Mucocutaneous Lymph Node Syndrome - blood Mucocutaneous Lymph Node Syndrome - diagnosis Mucocutaneous Lymph Node Syndrome - genetics Physicians Researchers Sequence Analysis, RNA Studies Support Vector Machine Veins & arteries
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Zusammenfassung:	Because males have a higher KD incidence rate than do females, we further investigated whether the 10 miRNAs are significantly differentially expressed between male and female subjects, causing bias when served as a disease biomarker. The expressions of the remaining 9 biomarker miRNAs were not sex specific. [...]we used the ΔCt values of the 10 miRNAs to develop a KD biomarker panel, training a Support Vector Machine (SVM) classification model, and diagnosing KD.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2016.04.050