Up-regulation of glutathione-related genes, enzyme activities and transport proteins in human cervical cancer cells treated with doxorubicin
Highlights • Expression of GSTA3 and GSTM1 is markedly higher in DOX-resistant KB-V1 cells. • DOX up-regulates expression of GSTA1, GSTA2, GSTA3 and GSTM1 in HeLa cells. • DOX up-regulates expression of GSTA1 and GSTA2 in KB-V1 cells. • MRP-mediated transport of DOX is not increased in HeLa or KB-V1...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2016-10, Vol.83, p.397-406 |
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| creator | Drozd, Ewa Krzysztoń-Russjan, Jolanta Marczewska, Jadwiga Drozd, Janina Bubko, Irena Bielak, Magda Lubelska, Katarzyna Wiktorska, Katarzyna Chilmonczyk, Zdzisław Anuszewska, Elżbieta Gruber-Bzura, Beata |
| description | Highlights • Expression of GSTA3 and GSTM1 is markedly higher in DOX-resistant KB-V1 cells. • DOX up-regulates expression of GSTA1, GSTA2, GSTA3 and GSTM1 in HeLa cells. • DOX up-regulates expression of GSTA1 and GSTA2 in KB-V1 cells. • MRP-mediated transport of DOX is not increased in HeLa or KB-V1 cells. |
| doi_str_mv | 10.1016/j.biopha.2016.06.051 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line, Tumor Cervical cancer Doxorubicin Doxorubicin - pharmacology Female Fluorescent Antibody Technique Gene Expression Regulation, Neoplastic - drug effects Glutathione Glutathione - metabolism Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Glutathione Reductase - genetics Glutathione Reductase - metabolism GST Humans Internal Medicine Medical Education Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Resistance Up-Regulation - drug effects Uterine Cervical Neoplasms - enzymology Uterine Cervical Neoplasms - genetics |
| title | Up-regulation of glutathione-related genes, enzyme activities and transport proteins in human cervical cancer cells treated with doxorubicin |
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